The COVID-19 pandemic has shaped the world in various ways over the past few years, and one of the most controversial developments is the discussion surrounding the long-term effects of COVID-19 vaccines. In this blog post, we take a scientific look at the so-called “pandemic of the vaccinated” and examine what the latest scientific findings have to say about it.

The Spike Protein: A Central Factor#

The spike protein, produced by mRNA vaccines, is at the center of many discussions. Studies have shown that this protein can persist in the body for an extended period. A study in medRxiv (2025; DOI: 10.1101/2025.02.18.25322379) found that the spike protein could be detected in some cases up to 700 days after vaccination ^1^. Another study in Human Vaccines & Immunotherapeutics confirmed that the S1 component of the spike protein could be detected in CD16+ monocytes up to 245 days after vaccination ^2^.

Persistence and Shedding#

The persistence of the spike protein raises questions about shedding, the process by which vaccinated individuals might release the protein. A study in the Journal of Clinical Neuroscience (2025) found spike protein in the cerebral arteries of vaccinated individuals up to 17 months after their last vaccination ^2^. This suggests that shedding might have a longer window than initially thought.

Health Impacts#

The long-term effects of the vaccines are another important topic. Studies suggest that the persistence of the spike protein could lead to chronic inflammation and an increased risk of neurodegenerative diseases such as Alzheimer’s or Parkinson’s ^3^. Additionally, there are reports of post-vaccination syndromes that resemble symptoms typically associated with Long COVID ^4^.

Immunological Reactions#

The vaccines can also trigger immunological dysregulation. A study in Human Vaccines & Immunotherapeutics found that the persistence of S1 in CD16+ monocytes is associated with an inflammatory profile that could contribute to post-vaccination symptoms ^5^. These inflammations could also increase susceptibility to other diseases.

Criticism and Controversies#

There are also critical voices questioning the safety and effectiveness of mRNA vaccines. A study in ScienceFiles (2025) claims that mRNA vaccines can stimulate the production of spike proteins over months, potentially leading to immune system dysregulation ^6^. Additionally, there are reports of the presence of spike protein in various organs, including the brain, raising concerns about potential neurological impacts ^7^.

Conclusion#

The “pandemic of the vaccinated” is a complex issue that involves many open questions and controversial discussions. While vaccines have played a crucial role in combating the COVID-19 pandemic, the latest scientific findings raise questions about their long-term effects and potential risks. It is important to conduct further research to gain a more comprehensive understanding of the impacts of COVID-19 vaccines and to minimize potential risks to public health.